Both teams enter the clash without their starters at quarterback, but the betting market still leans heavily toward the Buckeyes.
Key points
- Ohio State is favored by 7.5 points despite missing its starting quarterback.
- The over/under of 45.5 points is projected to hit in more than half of the model’s simulations.
- SportsLine’s model, which runs 10,000 simulations per game, has an 80‑77 season record on college‑football picks.
- Both teams’ backup quarterbacks posted strong performances last week, suggesting the offensive output could remain high.
The No. 12 Ohio State Buckeyes host No. 23 Oregon Ducks in a Week 10 Big Ten showdown at Ohio Stadium, with kickoff slated for 3:30 p.m. ET on CBS and Paramount+. The game marks the first meeting of the season between two top‑25 programs.
Ohio State arrives after a five‑game winning streak was snapped by an unranked USC team, a 30‑18 loss that left the Buckeyes at 6‑2 overall and 4‑1 in conference play. Oregon, meanwhile, rebounded from a 34‑26 upset of No. 20 Northwestern to sit at 5‑3 overall and 3‑2 in the Big Ten.
Key Injuries and Recent Form
Both squads are dealing with quarterback absences: senior Julian Sayin (arm) is out for Ohio State, while Oregon’s Dante Moore is sidelined with a concussion. Ohio State wide receiver Brandon Inniss is listed as doubtful for the contest.
Betting markets list Ohio State as 7.5‑point favorites (‑285 money line) with Oregon at +245. The over/under is set at 45.5 points. SportsLine’s projection model, which simulates each FBS game 10,000 times, predicts the total will go over in about 56 % of simulations and the spread will land on the favored side in over 60 % of runs.
Betting Lines and Model Outlook
The model’s track record adds weight to its forecasts: entering Week 10 it held an 80‑77 record on top‑rated college‑football picks across betting sites this season. The simulation also notes that the last four meetings between the programs have all exceeded 60 combined points, reinforcing the over‑prediction.
Fans can stream the game on Paramount+ and may encounter promotional offers from Kalshi and Polymarket referenced in the original CBS Sports article, though those offers are unrelated to the on‑field analysis.
Reader questions
When does the Ohio State vs. Oregon game start?
Kickoff is scheduled for 3:30 p.m. Eastern Time on the Saturday of Week 10.
What are the current betting lines for the matchup?
Ohio State is a 7.5‑point favorite with a ‑285 money line, Oregon is +245, and the over/under is set at 45.5 points.
How reliable is the SportsLine projection model?
According to the CBS Sports source, the model simulates each game 10,000 times and entered Week 10 with an 80‑77 record on top‑rated college‑football picks this season.
Source: cbssports.com
